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FLASH GENE
Symbol BAG5 contributors: - updated : 04-09-2006
HGNC name BCL2-associated athanogene 5
HGNC id 941
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four BAG domains
  • a C terminal BAG domain binding Hsc70/Hsp70
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • inhibiting parkin and enhancing dopaminergic neuron degeneration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the atpase domain of HSP70/hsc chaperones
  • binds PARK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS