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FLASH GENE
Symbol BAG5 contributors: - updated : 04-09-2006
HGNC name BCL2-associated athanogene 5
HGNC id 941
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Endocrineneuroendocrinepituitary  highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four BAG domains
  • a C terminal BAG domain binding Hsc70/Hsp70
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • inhibiting parkin and enhancing dopaminergic neuron degeneration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the atpase domain of HSP70/hsc chaperones
  • binds PARK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS