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FLASH GENE
Symbol BAG2 contributors: mct - updated : 18-09-2007
HGNC name BCL2-associated athanogene 2
HGNC id 938
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three BAG domains of BAG1, BAG2, and BAG3 interact specifically with the HSPA8 ATPase domain
  • C terminal BAG domain binding HSPA8/HSP70 ATPase domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release
  • compete with RPL29 for binding to the HSPA8/HSP70 ATPase domain and promote substrate release
  • inhibits the ubiquitin ligase activity of STUB1 by abrogating the STUB1/E2 cooperation and stimulates the chaperone-assisted maturation of CFTR
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the ATPase domain of HSP70/HSC chaperones
  • associates with STUB1 as part of a ternary complex with HSPA8, and BAG2 (provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by STUB1)
  • BAG2 contributes to HSP70 stabilization in tissues other than testes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS