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FLASH GENE
Symbol BAG2 contributors: mct - updated : 18-09-2007
HGNC name BCL2-associated athanogene 2
HGNC id 938
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D6S294 - BAG2 - D6S257 - D6S1695 - D6S1658 - D6S430 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three BAG domains of BAG1, BAG2, and BAG3 interact specifically with the HSPA8 ATPase domain
  • C terminal BAG domain binding HSPA8/HSP70 ATPase domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release
  • compete with RPL29 for binding to the HSPA8/HSP70 ATPase domain and promote substrate release
  • inhibits the ubiquitin ligase activity of STUB1 by abrogating the STUB1/E2 cooperation and stimulates the chaperone-assisted maturation of CFTR
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the ATPase domain of HSP70/HSC chaperones
  • associates with STUB1 as part of a ternary complex with HSPA8, and BAG2 (provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by STUB1)
  • BAG2 contributes to HSP70 stabilization in tissues other than testes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS