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FLASH GENE

Symbol

MYCBP

contributors: mct - updated : 17-11-2017

HGNC name	c-myc binding protein
HGNC id	7554

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p33-p32.2      Physical location : 39.328.636 - 39.339.050
Synonym name	associate of MYC-1
Synonym symbol(s)	AMY1, AMY-1, MBP-1

DNA

TYPE	functioning gene
STRUCTURE	10.00 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 2093 - 103 - Sedoris (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system placenta     highly   male system testis     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal region involved in all the biologic functions of MYC

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
text	mostly expressed in the cytoplasm translocating into the nucleus for c-myc (MYC) expression
	localizes to the trans-Golgi network (TGN)

basic FUNCTION	stimulating the activation of the E-box regulated transcription by MYC/MAX
	playing roles in spermatogenesis
	may play a central role in regulating the abnormal proliferative characteristics of transformed cells
	playing an important role in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

MYCBP forms a complex with GLI and SUFU without HH stimulation but remains inactive

INTERACTION

DNA

RNA

small molecule

protein	c-myc binding, interacting with the N terminal transactivation domain of MYC
	with MYCBPAP
	binding to the N-terminal half of AKAP1 in a quaternary complex with C3orf15 and a regulatory subunit (RII) of cAMP-dependent kinase (PKA)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS