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FLASH GENE
Symbol ENOX2 contributors: mct - updated : 19-10-2016
HGNC name ecto-NOX disulfide-thiol exchanger 2
HGNC id 2259
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three potential N-linked glycosylation sites
  • multiple potential phosphorylation sites
  • C-terminal portion corresponding to the processed plasma membrane-associated form include quinone (capsaicin), copper and adenine nucleotide binding domains
  • two cysteines essential for catalytic activity
    • conjugated GlycoP , MetalloP
    HOMOLOGY
    interspecies ortholog to murine Cova1
    Homologene
    FAMILY ENOX family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, but is absent from the surface of noncancer cells and from sera from healthy individuals
  • contributing to the enlargement phase of cell growth
  • growth-related protein expressed in transformed cells
  • is present in the serum of cancer patients several years before the clinical symptoms of the tumor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component recognized by monoclonal antibody Mab-KI
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • quinone (capsaicin)
  • bound copper emerges as having an essential role in ENOX2 both for enzymatic activity and for the structural changes that underly the periodic alternations in activity that define the time-keeping cycle of the protein
  • ATP
    • protein
  • HNRNPF directs formation of the exon 4 minus variant of ENOX2
  • capsaicin inhibits the growth of bladder cancer cells by inhibiting ENOX2 and SIRT1 and thereby reducing proliferation, attenuating migration, and prolonging cell cycle progression
    • cell & other
    REGULATION
    Phosphorylated by PRKCD, and phosphorylation of serine-504 by PRKCD modulates the biological function of ENOX2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    its inhibition is potentially a hope of improving cancer therapy
    ANIMAL & CELL MODELS