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FLASH GENE
Symbol CH25H contributors: mct/npt - updated : 07/11/2008
HGNC name cholesterol 25-hydroxylase
HGNC id 1907
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • sterol desaturase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • cholesterol 25-hydrolase
  • polytopic membrane protein containing clusters of histidine residues essential for catalytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • potent oxysterol regulator of lipid metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • diiron Fe2+ utilized to catalyze the hydroxylation of hydrophobic substrates
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Alzheimer disease (AD)
    Variant & Polymorphism other role of the haplotype CH25Hchi4 as a putative susceptibility factor for sporadic AD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS