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FLASH GENE
Symbol CH25H contributors: mct/npt - updated : 07/11/2008
HGNC name cholesterol 25-hydroxylase
HGNC id 1907
Location 10q23      Physical location : 90.965.695 - 90.967.071
Synonym name cholesterol 25-monooxygenase
Synonym symbol(s) h25OH, C25H
EC.number 1.14.99.38
DNA
TYPE functioning gene
STRUCTURE 1.37 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure intronless
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1378 31 272 - Deloukas (2004)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 pharynx    
Endocrineadrenal gland    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • sterol desaturase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • cholesterol 25-hydrolase
  • polytopic membrane protein containing clusters of histidine residues essential for catalytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • potent oxysterol regulator of lipid metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • diiron Fe2+ utilized to catalyze the hydroxylation of hydrophobic substrates
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Alzheimer disease (AD)
    Variant & Polymorphism other role of the haplotype CH25Hchi4 as a putative susceptibility factor for sporadic AD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS