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FLASH GENE
Symbol CLDN9 contributors: mct/npt - updated : 11-04-2023
HGNC name claudin 9
HGNC id 2051
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments
    • HOMOLOGY
    Homologene
    FAMILY
  • claudin family
    • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • integral membrane protein and constituent of epithelial bicellular tight junctions (TJs)
    • basic FUNCTION
  • tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • able to mediate HCV entry just as efficiently as CLDN1 and able to mediate the entry of HCV into target cells (Zheng 2007)
  • with CLDN1 and CLDN6, are entry cofactors for hepatitis C virus HCV (Meertens 2008)
  • required for the preservation of sensory cells in the hearing organ because claudin-9–defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph (Nakano 2009)
  • its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs (Nakano 2009)
  • essential role for claudin-9 in promoting lung cancer metastasis
  • likely CLDN9 plays a role in the formation of TJs associated with dense cytoplasmic plaques
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • is a major component of TJs in the Folliculo-stellate (FS) cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDRG1 is important to maintain the integrity of airway epithelial barrier through CLDN9 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB116
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant CLDN9 expression is a predictor of poor prognosis for endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could potentially be used as a diagnostic and/or prognostic marker for subtypes of pituitary adenomas (
  • CLDN9 may be an important biomarker for invasive pituitary oncocytomas
    • Therapy target
    SystemTypeDisorderPubmed
    tumor  
    could potentially be used as an immunotherapy target for subtypes of pituitary adenomas
    ANIMAL & CELL MODELS
    ENU–induced mouse mutant (nmf329) with Claudin 9 mutation exhibits recessively inherited deafness (Nakano 2009)