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FLASH GENE

Symbol

NODAL

contributors: mct - updated : 22-11-2016

HGNC name	nodal homolog (mouse)
HGNC id	7865

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HTX5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in metastatic melanomas constitutional germinal mutation       cause sporadic left–right (LR) patterning defects constitutional       loss of function reductions in the biological activity of NODAL alleles in congenital heart defects tumoral     --over   expression levels are significantly higher in astrocytomas, glioblastomas, oligodendrogliomas, and in malignant glioma cells compared with non-tumor tissues tumoral     --over   correlated with reduced patient survival in pancreatic cancer constitutional     --low   decreased expression of NODAL combined with haploinsufficiency for FOXA2 is the likely cause for heterotaxy, panhypopituitarism, and biliary atresia in a family (pMID: 25765999)

Susceptibility

to congenital heart disease (CHD)

Variant & Polymorphism other	contribution to CHD of copy number changes in NODAL

Candidate gene
Marker
Therapy target	inhibition of Nodal signaling may be considered as a novel therapeutic strategy in glioma treatment

ANIMAL & CELL MODELS