Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IDH3B contributors: mct - updated : 10-12-2020
HGNC name isocitrate dehydrogenase 3 (NAD+) beta
HGNC id 5385
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,nucleus
basic FUNCTION
  • involved in the third step of citric acid cycle
  • playing a regulatory role in determining the pH optimum for IDH activity through the tissue-specific alternative splicing
  • is an important regulator of the cell cycle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARRP17
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC), IDH3B was posttranslationally upregulated in late G1 phase, and overexpression of IDH3B accelerated G1-S transition, contributing to the promotion of cell proliferation
    Susceptibility to uterine prolapse
    Variant & Polymorphism SNP
  • SNP rs6051098 is associated with uterine prolapse
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS