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FLASH GENE

Symbol

IDH3B

contributors: mct - updated : 10-12-2020

HGNC name	isocitrate dehydrogenase 3 (NAD+) beta
HGNC id	5385

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Reproductive female system uterus cervix   highly   female system ovary     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,nucleus

basic FUNCTION	involved in the third step of citric acid cycle
	playing a regulatory role in determining the pH optimum for IDH activity through the tissue-specific alternative splicing
	is an important regulator of the cell cycle

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARRP17

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous cell carcinoma (ESCC), IDH3B was posttranslationally upregulated in late G1 phase, and overexpression of IDH3B accelerated G1-S transition, contributing to the promotion of cell proliferation

Susceptibility

to uterine prolapse

Variant & Polymorphism SNP	SNP rs6051098 is associated with uterine prolapse

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS