Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

IDH3B

contributors: mct - updated : 10-12-2020

HGNC name	isocitrate dehydrogenase 3 (NAD+) beta
HGNC id	5385

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.82 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	two alternatively spliced isoforms beta 1 (in non muscle tissues) and beta 2 (in heart and skeletal muscle)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006899 12 - 1542 NP_008830 - 385 - 2010 20435888 NM_174855 12 - 1227 NP_777280 - 383 - 2010 20435888 variant 3 11 - 1645 - 233 - 2010 20435888 NM_001330763 13 - 1305 NP_001317692 - 387 - 2010 20435888 NM_001258384 12 - 1397 NP_001245313 - 376 - 2010 20435888

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Reproductive female system uterus cervix   highly   female system ovary     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,nucleus

basic FUNCTION	involved in the third step of citric acid cycle
	playing a regulatory role in determining the pH optimum for IDH activity through the tissue-specific alternative splicing
	is an important regulator of the cell cycle

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARRP17

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous cell carcinoma (ESCC), IDH3B was posttranslationally upregulated in late G1 phase, and overexpression of IDH3B accelerated G1-S transition, contributing to the promotion of cell proliferation

Susceptibility

to uterine prolapse

Variant & Polymorphism SNP	SNP rs6051098 is associated with uterine prolapse

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS