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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CD22

contributors: mct/pgu - updated : 14-02-2011

HGNC name	CD22 molecule
HGNC id	1643

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     splicing defect that causes the deletion of exon 12 (CD22&916;E12) results in a truncating frameshift mutation, with B-precursor leukemia

Susceptibility

potential susceptibility gene for autoimmune diseases

Variant & Polymorphism

Candidate gene	Aberrant CD22 expression is a useful marker for detection of monoclonal B cells admixed with numerous benign polyclonal B cells
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   antisense oligonucletides can be designed as an innovative strategy with therapeutic intent in B-precursor leukemia to shift the CD22 splicing pattern by preventing exclusion of exon 12 in the CD22 mRNA by targeting and sterically blocking the splice site

ANIMAL & CELL MODELS