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FLASH GENE
Symbol CD22 contributors: mct/pgu - updated : 14-02-2011
HGNC name CD22 molecule
HGNC id 1643
DNA
TYPE functioning gene
STRUCTURE 18.19 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • exons 3
    • 9 each encode a single Ig domain, exon 10 encodes the transmembrane domain, whereas the cytoplasmic tail is encoded by exons 11
    14
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3300 - 847 - 2009 19150402
    12 - 2769 - 670 - 2010 20841423
    13 - 3036 - 759 - 2010 20841423
    13 - 3181 - 751 - 2010 20841423
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven Ig-like extracellular domains (exons 3–9 each encode a single Ig domain)
  • a transmembrane domain encoded by exon 10
  • a PTPN6-binding domain at the region containing Tyr(843) and Tyr(863)
  • a long cytoplasmic tail with two immunoreceptor tyrosine based inhibitory motifs (ITIM), encoded by exons 11–14, constituting a novel conditional PTPN6-binding site of CD22 that is activated upon BCR ligation by antigen but not by anti-Ig Antibody
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
    • CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in the regulation of B cell activation sialoadhesin
  • attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity
  • regulator of B-cell signaling, exhibiting hallmarks of clathrin-mediated endocytosis and traffics to recycling compartments, consistent with previous reports demonstrating its localization to clathrin domains
  • regulates time course of both B cell division and antibody response
  • B lymphocyte specific response regulator, which is down-regulated after B-cell activation
  • inhibitory coreceptor of B-cells and B-cell precursors that acts as a negative regulator of multiple signal transduction pathways critical for B-cell homeostasis, survival, activation, and differentiation
  • with SIGLEC10 have partly compensatory functions and together are crucial in maintaining the B cell tolerance
  • CD22 and TNFSF13B promote the survival of overlapping B-cell subsets but contribute to their maintenance through independent and complementary signaling pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with SH2D1A (leads to constitutive CD22 tyrosine phosphorylation and decreased Ca(2+) response in B cells)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    splicing defect that causes the deletion of exon 12 (CD22&916;E12) results in a truncating frameshift mutation, with B-precursor leukemia
    Susceptibility potential susceptibility gene for autoimmune diseases
    Variant & Polymorphism
    Candidate gene Aberrant CD22 expression is a useful marker for detection of monoclonal B cells admixed with numerous benign polyclonal B cells
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    antisense oligonucletides can be designed as an innovative strategy with therapeutic intent in B-precursor leukemia to shift the CD22 splicing pattern by preventing exclusion of exon 12 in the CD22 mRNA by targeting and sterically blocking the splice site
    ANIMAL & CELL MODELS