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FLASH GENE
Symbol UBE2V2 contributors: mct - updated : 21-10-2011
HGNC name ubiquitin-conjugating enzyme E2 variant 2
HGNC id 12495
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an acidic domain
  • a C terminal basic domain, lacking the critical cysteine residue essential for E2 catalytic activity
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in the control of differentiation
  • ubiquitin dependent proteolytic protein
  • UBE2V2 along with its heteromeric partner UBE2N can govern the error-free repair of DNA lesions by catalyzing the formation of lysine 63-linked polyubiquitin chains (K63-polyUb)
  • serves a redundant role in human PCNA polyubiquitination
    • CELLULAR PROCESS cell life, differentiation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with UBE2N (UBE2N-UBE2V2 is required for DNA damage repair but not nuclear factor kappaB (NF-kappaB) activation)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2V2 physical association with Ub is correlated with its ability to promote Lys63-linked Ub chain assembly (
  • interactions between TRIM32 and UBE2V2, and UBE2V1
  • UBE2N is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS