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FLASH GENE

Symbol

SPAST

contributors: mct/npt/pgu/shn - updated : 27-08-2013

HGNC name	spastin
HGNC id	11233

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPG4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	cells lacking the MT-severing protein spastin had increased tubulation of and defective receptor sorting through endosomal tubular recycling compartments
	Zebrafish spinal motor axons depleted of spastin has abnormal endosomal tubulation