SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton
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| text
| in non-infected macrophages, associated with the cortical microtubule network |
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in mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes |
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localize at the leading edge of lamellipodia  |
| basic FUNCTION
| playing a role in the signal transduction pathway of chemotaxis |
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may be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion |
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required for actin-dependent changes in cell morphology that lead to migration and phagocytosis |
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in mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes |
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may play crucial roles in leukocyte functions, including cell migration and phagocytosis |
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having a function in T cell egress, is involved in Arp2/3 regulation |
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actin-binding protein that can associate with phagosomes and NADPH oxidase |
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acts as a regulator of F-actin dynamics and Ca2+ signaling |
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its activity is not required for mast cell function |
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CORO1A-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis |
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essential regulator of the balance between prosurvival and proapoptotic signals in naive T cells |
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non-redundant role in the regulation of Th17 CD4(+) cell effector functions and, subsequently, in the development of autoimmunity |
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key player in T cell survival, migration, activation, and Ca(2+) regulation in naive T cells |
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promotes a cytoskeletal-based feedback loop that facilitates RAC1 translocation and activation |
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controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages |
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in contrast with CORO1A and CORO1B, CORO1C displays highly co-operative binding to actin filaments |
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involved in the activation of the Ca(2+)/calcineurin signaling pathway following cell surface stimulation in T cells, B cells as well as macrophages |
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is dispensable for antigen processing and presentation by dendritic cells |
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plays a differential role in CD8(+) versus CD4(+) T cell responses and activation |
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is a neurotrophin endosomal effector that is required for developmental competition for survival |
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cytoskeleton-related CORO1A and CORO1B proteins control a myosin II inactivation-dependent step that dictates the intracellular dynamics and cytoskeletal output of active RAC1 |
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CORO1A, CORO1B are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling |
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plays a role in natural killer cell cytotoxic function and in neurobehavioral processes |
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is a regulator of actin dynamics important for T-cell homeostasis, through its oligomerization and subcellular localization |
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predominant T cell-intrinsic role of Coronin 1A |
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role of CORO1A in neural development and function |
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represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils (PMNs)trafficking during innate immunity |
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