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FLASH GENE
Symbol CORO1A contributors: mct/npt/pgu - updated : 30-08-2017
HGNC name coronin, actin binding protein, 1A
HGNC id 2252
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1620 50.9 461 - 2006 16902139
12 - 1943 - 461 - 2006 16902139
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
Lymphoid/Immunelymph node    
 spleen   moderately
 thymus   highly
 tonsils   predominantly
Nervousbrain    
Respiratorylung   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
 bone marrow  highly Homo sapiensAdult
Connectivebone   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythrocyte Homo sapiensAdult
Blood/Hematopoieticneutrophil Homo sapiensAdult
Blood/Hematopoieticplatelet Homo sapiensAdult
cell lineage
cell lines
fluid/secretion moderately in blood and lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five WD40(tryptophan/aspartic acid) repeats
  • a coiled-coil motif
  • a leucine zipper domain at the C-terminus
  • conjugated Other
    HOMOLOGY
    interspecies homolog to rattus Coro1a (93.9pc)
    homolog to murine Coro1a (94.6pc)
    Homologene
    FAMILY
  • WD repeat coronin family
  • CATEGORY adhesion , structural protein , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton
    text
  • in non-infected macrophages, associated with the cortical microtubule network
  • in mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes
  • localize at the leading edge of lamellipodia
  • basic FUNCTION
  • playing a role in the signal transduction pathway of chemotaxis
  • may be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion
  • required for actin-dependent changes in cell morphology that lead to migration and phagocytosis
  • in mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes
  • may play crucial roles in leukocyte functions, including cell migration and phagocytosis
  • having a function in T cell egress, is involved in Arp2/3 regulation
  • actin-binding protein that can associate with phagosomes and NADPH oxidase
  • acts as a regulator of F-actin dynamics and Ca2+ signaling
  • its activity is not required for mast cell function
  • CORO1A-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis
  • essential regulator of the balance between prosurvival and proapoptotic signals in naive T cells
  • non-redundant role in the regulation of Th17 CD4(+) cell effector functions and, subsequently, in the development of autoimmunity
  • key player in T cell survival, migration, activation, and Ca(2+) regulation in naive T cells
  • promotes a cytoskeletal-based feedback loop that facilitates RAC1 translocation and activation
  • controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages
  • in contrast with CORO1A and CORO1B, CORO1C displays highly co-operative binding to actin filaments
  • involved in the activation of the Ca(2+)/calcineurin signaling pathway following cell surface stimulation in T cells, B cells as well as macrophages
  • is dispensable for antigen processing and presentation by dendritic cells
  • plays a differential role in CD8(+) versus CD4(+) T cell responses and activation
  • is a neurotrophin endosomal effector that is required for developmental competition for survival
  • cytoskeleton-related CORO1A and CORO1B proteins control a myosin II inactivation-dependent step that dictates the intracellular dynamics and cytoskeletal output of active RAC1
  • CORO1A, CORO1B are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling
  • plays a role in natural killer cell cytotoxic function and in neurobehavioral processes
  • is a regulator of actin dynamics important for T-cell homeostasis, through its oligomerization and subcellular localization
  • predominant T cell-intrinsic role of Coronin 1A
  • role of CORO1A in neural development and function
  • represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils (PMNs)trafficking during innate immunity
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • cell mobility
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • acetylation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin
  • ARPC5 and CORO1A interact with RNF128
  • constitutive turnover of phosphorylation at Thr-412 of CORO1A regulates its interaction with actin
  • essential role for YWHAZ in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of CORO1A
  • in primary T cells, regulatory role of CORO1A on PRKCQ recruitment and function downstream of the TCR leading to NFKB1 transactivation
  • cell & other
  • microtubule
  • REGULATION
    repressed by chenodeoxycholic acid (CDCA), either alone or in combination with retinoic acid (RA)
    Phosphorylated by protein kinase C, and the phosphorylation down-regulates the association of this protein with actin
    Other phosphorylation of CORO1A down-regulates its association with actin and modulates the reorganization of actin-containing cytoskeleton
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    could constitute a potential target in resolving inflammation
    ANIMAL & CELL MODELS
  • coronin 1-/- mice
  • Coro1a(-/-) mice display sympathetic axon overgrowth and overbranching phenotypes in the developing heart