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FLASH GENE
Symbol PEX10 contributors: mct/npt - updated : 29/10/2008
HGNC name peroxisome biogenesis factor 10
HGNC id 8851
Corresponding disease
PBD5 peroxisome biogenesis disorder, Zellweger spectrum
Location 1p36.33      Physical location : 2.336.242 - 2.344.010
Synonym name
  • peroxin 10, complementation group 7 (KKI)
  • peroxisome assembly protein 10
  • Synonym symbol(s) PEX10P, MGC1998, NALD, RNF69
    DNA
    TYPE functioning gene
    STRUCTURE 7.77 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D1S243 - [GNB1 - CDC2L1 ] - D1S468 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2094 39.1 346 - Okumoto, Gregory (2006)
    - - 2034 37 326 - Okumoto, Gregory (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Reproductivemale systemprostate  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative transmembrane segments
  • a C3HC4 zinc finger RING motif, exhibiting E3 ligase activity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • involved in import of peroxisomal matrix proteins
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text peroxisome
    PATHWAY
    metabolism
    signaling
    a component
  • component with PEX12 of a peroxisomal membrane complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PEX12 and PXR1 (PEX5) downstream of receptor docking in peroxisomal matrix transport import
  • acting as the E3 ligase for the UBE2D1-dependent ubiquitination of PEX5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBD5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS