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FLASH GENE

Symbol

SEZ6L

contributors: mct/npt - updated : 24-10-2009

HGNC name	seizure related 6 homolog (mouse)-like
HGNC id	10763

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in lung and breast cancer tumoral       loss of function by hypermethylation in colorectal cancer

Susceptibility

to lung cancer

Variant & Polymorphism other	role of the SEZ6L Met430Ile polymorphic variant in increasing lung cancer risk (Gorlov 2007)

Candidate gene	candidate gene for epilepsy (Yu 2007)
	DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
Marker
Therapy target

ANIMAL & CELL MODELS