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FLASH GENE

Symbol

SEZ6L

contributors: mct/npt - updated : 24-10-2009

HGNC name	seizure related 6 homolog (mouse)-like
HGNC id	10763

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021115 17 - 3424 NP_066938 109.1 1024 - Nishioka (2000)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Nervous brain       specific Respiratory lung       highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	multiple domains involved in protein - protein interaction and signal transduction (Nishioka 2000)
	short consensus repeats, sushi structure
	CUB domain

HOMOLOGY

interspecies

homolog to murine seizure related gene 6 -like

intraspecies

homolog to PSK1

Homologene

FAMILY

SEZ6 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in lung and breast cancer tumoral       loss of function by hypermethylation in colorectal cancer

Susceptibility

to lung cancer

Variant & Polymorphism other	role of the SEZ6L Met430Ile polymorphic variant in increasing lung cancer risk (Gorlov 2007)

Candidate gene	candidate gene for epilepsy (Yu 2007)
	DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
Marker
Therapy target

ANIMAL & CELL MODELS