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FLASH GENE

Symbol

SPRR1A

contributors: mct - updated : 16-05-2023

HGNC name	small proline-rich protein 1A
HGNC id	11259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered in the epidermal differentiation complex (EDC)
STRUCTURE	1.73 kb     1 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

open reading frame in a single exon

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - SPRR4 - SPRR1A - SPRR3 - SPRR1B - SPRR2D - SPRR2A - SPRR2B - SPRR2E - SPRR2F - SPRR2C - SPRR2G - tel
Authors	cabral et al.(01)
Text	see S100A@ ,EDC@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001199828 2 - 662 NP_001186757 - 89 - 1997 9008234 NM_005987 2 - 648 NP_005978 - 89 - 1997 9008234

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage	precursor of cornified cell envelope
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

small proline rich protein with a central segment built up from eight octapeptide repeats,*K*PEP*

HOMOLOGY

Homologene

FAMILY

SPRR protein family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
text	cornifin

basic FUNCTION	involved in the differentiation of epidermal keratinocytes
	SPRR proteins displayed potent bactericidal activity, exerting their bactericidal activity through binding and disruption of the bacterial membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

clustered in the epidermal differentiation complex (EDC)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   significantly increased in atopic dermatitis (AD) skin tumoral     --over   significantly increased in colorectal cancer tissues compared with those in adjacent non-cancerous tissues, and associated with a significantly worse event- and relapse-free survival time tumoral     --over   associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a potential biomarker for the prognosis of colon cancer
	may serve as a novel prognostic marker in pancreatic ductal adenocarcinoma (PDAC)
Therapy target

ANIMAL & CELL MODELS