basic FUNCTION
| a key regulator of alternative exon splicing in the nervous system and other cell types |
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may be acting as a coregulatory factor of ESR1 |
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potentially involved in RNA distribution and splicing |
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playing a role in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing |
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play an important role in determining tissue specificity of UGCAUG-mediated alternative splicing |
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acts as an RNA-binding protein that functions as potent repressor of steroid receptor-mediated transcriptional activity |
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functions as a critical regulator of a splicing network, |
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and has a vital role in the biology of human embryonic stem cells |
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RBFOX1, RBFOX2 potent regulators of alternative splicing in the heart, skeletal muscle, and brain, repress calcitonin-specific splicing of the calcitonin/CGRP pre-mRNA |
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may have a crucial role in establishing and |
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maintaining the splicing and signaling programs in hESCs |
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may function as an upstream regulator of many general and tissuespecific splicing regulators |
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RBFOX1 and RBFOX2 are not fully redundant in their neuronal functions |
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controls a post-transcriptional program required for proper brain development |
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is subsequently required with RBFOX1 to maintain mature neuronal physiology, specifically Purkinje cell pacemaking, through their shared control of sodium channel transcript splicing |
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is an important driver of mesenchymal tissue-specific splicing |
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MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation |
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cross-regulates alternative splicing-coupled nonsense-mediated decay (AS-NMD) events within RNA-binding proteins to alter their expression |
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RBFOX2-coordinated alternative splicing of MEF2D and ROCK2 controls myoblast fusion during myogenesis |
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RNA-binding protein involved in tissue specific alternative splicing regulation and steroid receptors transcriptional activity |
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RBFOX2 isoform distribution may play a fundamental role in RBFOX2-specific cellular effects |
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new role for RBFOX1, RBFOX2 proteins in regulating myogenesis through activation of essential muscle-specific splicing events |