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FLASH GENE

Symbol

MAPK8IP2

contributors: mct - updated : 23-05-2012

HGNC name	mitogen-activated protein kinase 8 interacting protein 2
HGNC id	6883

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       is a contributing genetic factor in Chr22qter-associated cognitive disorders

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

disruption of the Mapk8ip2 gene in mice reduces AMPA and enhances NMDA receptor-mediated glutamatergic transmission in cerebellum, changes the morphology of Purkinje cell dendritic arbors, and induces motor and cognitive deficits