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FLASH GENE
Symbol MAPK8IP2 contributors: mct - updated : 23-05-2012
HGNC name mitogen-activated protein kinase 8 interacting protein 2
HGNC id 6883
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal JNK binding domain (IBD)
  • a proline-rich and an acidic region
  • a SH3 domain
  • a phosphotyrosine interacting domain (PID) at the C terminus
    • mono polymer homomer
    HOMOLOGY
    interspecies homolog to murine Jir1 gene
    Homologene
    FAMILY MAP (mitogen activated protein) kinase family
    CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text highly enriched within postsynaptic densities
    basic FUNCTION
  • regulating the JNK signaling pathway in brain and pancreatic beta cells
  • decreasing IL1B induced apoptosis in beta-cells
  • scaffold protein critically required for normal NMDA receptor function
  • scaffold molecule that are implicated in the regulation of the JNK
  • MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    signaling module in which MAPK8IP2 scaffolds a MLK3/MKK/MAPK13 cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAP2K8
  • MAP2K7
  • MAPK8
  • weaker APP-binding protein
  • FGF12 and FGF13 aid in recruitment of MAPK14 to MAPK8IP2 and may serve as kinase substrates
  • bind to FGF12, but did not interfere with the anti-apoptotic effect of FGF12
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    is a contributing genetic factor in Chr22qter-associated cognitive disorders
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of the Mapk8ip2 gene in mice reduces AMPA and enhances NMDA receptor-mediated glutamatergic transmission in cerebellum, changes the morphology of Purkinje cell dendritic arbors, and induces motor and cognitive deficits