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FLASH GENE

Symbol

MAPK8IP2

contributors: mct - updated : 23-05-2012

HGNC name	mitogen-activated protein kinase 8 interacting protein 2
HGNC id	6883

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	10.85 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - D22S272 - D22S423 - XRCC6 - NAGA NAGA - D22S276 D22S282 - D22S1171 - D22S1140 - MAPK8IP1 - D22S1160 - D22S1141 - D22S274 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012324 12 - 3381 NP_036456 - 824 - 2000 10756100 NM_016431 10 - 3183 NP_057515 - 797 - 2000 10756100

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal JNK binding domain (IBD)
	a proline-rich and an acidic region
	a SH3 domain
	a phosphotyrosine interacting domain (PID) at the C terminus

mono polymer

homomer

HOMOLOGY

interspecies

homolog to murine Jir1 gene

Homologene

FAMILY

MAP (mitogen activated protein) kinase family

CATEGORY

chaperone/stress , enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	highly enriched within postsynaptic densities

basic FUNCTION	regulating the JNK signaling pathway in brain and pancreatic beta cells
	decreasing IL1B induced apoptosis in beta-cells
	scaffold protein critically required for normal NMDA receptor function
	scaffold molecule that are implicated in the regulation of the JNK
	MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

signaling module in which MAPK8IP2 scaffolds a MLK3/MKK/MAPK13 cascade

a component

INTERACTION

DNA

RNA

small molecule

protein	MAP2K8
	MAP2K7
	MAPK8
	weaker APP-binding protein
	FGF12 and FGF13 aid in recruitment of MAPK14 to MAPK8IP2 and may serve as kinase substrates
	bind to FGF12, but did not interfere with the anti-apoptotic effect of FGF12

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       is a contributing genetic factor in Chr22qter-associated cognitive disorders

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

disruption of the Mapk8ip2 gene in mice reduces AMPA and enhances NMDA receptor-mediated glutamatergic transmission in cerebellum, changes the morphology of Purkinje cell dendritic arbors, and induces motor and cognitive deficits