basic FUNCTION
| regulator of epithelial cell polarity |
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is likely a key negative regulator of insulin secretion |
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supports motor performance by regulation of transmitter release willingness to sustain synaptic strength during high-frequency transmission |
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negative regulator of exocytosis, and causes an attenuation of insulin secretion by limiting the formation of the SNARE complex |
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enhanced phosphorylation of a negative regulator of secretion, STXBP5L, in response to insulin secretagogues targets it to degradation by the SYVN1 E3-ubiquitin ligase |
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inhibit neurotransmitter release through inhibition of the formation of the SNARE complexes between synaptic vesicles and the plasma membrane |
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STXBP5L and STXBP5 regulate docking and fusion of synaptic vesicles with the presynaptic membrane, a process of crucial importance for normal neurotransmission (pMID: 25504045) |