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FLASH GENE
Symbol SIK3 contributors: mct - updated : 14-06-2016
HGNC name SIK family kinase 3
HGNC id 29165
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protein kinase domain
  • a UBA domain
    • HOMOLOGY
    interspecies homolog to murine putative S/T kinase MSK
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a serine/threonine kinase
  • essential role for SIK3 in facilitating chondrocyte hypertrophy during skeletogenesis and growth plate maintenance
  • SIK3 induces nuclear export of the deacetylases independent of kinase activity and 14-3-3 binding
  • SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex and thereby the inhibition of ubiquitination of TRAF6
  • mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
  • likely developmental role of SIK3 in hearing and may be required for the maintenance of adult auditory function
  • is a unique negative regulator that suppresses inflammatory molecule gene expression in LPS-stimulated macrophages
  • SIK3, rather than SIK1, SIK2, or AMPKs, acts as the predominant suppressor in gluconeogenic gene expression in the hepatocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • STK11-SIK pathway functions as a key gluconeogenic gatekeeper in the liver
    • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • STK11 acts through SIK2 and SIK3 to promote nucleocytoplasmic trafficking of class IIa HDACs
  • SIK1 and SIK3 negatively regulate TTLR4-mediated signal
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • biliary disorders in Sik3(-/-) mice are associated with the dysregulation of gene expression programs that respond to nutritional stresses and are probably regulated by nuclear receptors
  • Sik3-deficient mice showed dwarfism as they aged, whereas body size was unaffected during embryogenesis