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FLASH GENE

Symbol

SIK3

contributors: mct - updated : 14-06-2016

HGNC name	SIK family kinase 3
HGNC id	29165

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       moderately Endocrine thyroid       highly Nervous nerve       highly Reproductive female system placenta     moderately Respiratory lung       highly   respiratory tract larynx     predominantly Visual eye       moderately

cell lineage
cell lines
fluid/secretion	moderately in blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a protein kinase domain
	a UBA domain

HOMOLOGY

interspecies

homolog to murine putative S/T kinase MSK

Homologene

FAMILY	protein kinase superfamily
	Ser/Thr protein kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	acting as a serine/threonine kinase
	essential role for SIK3 in facilitating chondrocyte hypertrophy during skeletogenesis and growth plate maintenance
	SIK3 induces nuclear export of the deacetylases independent of kinase activity and 14-3-3 binding
	SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex and thereby the inhibition of ubiquitination of TRAF6
	mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
	likely developmental role of SIK3 in hearing and may be required for the maintenance of adult auditory function
	is a unique negative regulator that suppresses inflammatory molecule gene expression in LPS-stimulated macrophages
	SIK3, rather than SIK1, SIK2, or AMPKs, acts as the predominant suppressor in gluconeogenic gene expression in the hepatocytes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

STK11-SIK pathway functions as a key gluconeogenic gatekeeper in the liver

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	STK11 acts through SIK2 and SIK3 to promote nucleocytoplasmic trafficking of class IIa HDACs
	SIK1 and SIK3 negatively regulate TTLR4-mediated signal

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	biliary disorders in Sik3(-/-) mice are associated with the dysregulation of gene expression programs that respond to nutritional stresses and are probably regulated by nuclear receptors
	Sik3-deficient mice showed dwarfism as they aged, whereas body size was unaffected during embryogenesis