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FLASH GENE
Symbol SIK3 contributors: mct - updated : 14-06-2016
HGNC name SIK family kinase 3
HGNC id 29165
Location 11q23.3      Physical location : 116.714.119 - 116.968.993
Synonym name
  • related to murine putative S/T kinase MSK
  • salt-inducible kinase 3
  • serine/threonine-protein kinase QSK
    • Synonym symbol(s) L19, FLJ12240, SIK-3, KIAA0999, QSK
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 254.88 kb     24 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 6072 140 1263 - Al-Hakim (2005)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   moderately
    Endocrinethyroid   highly
    Nervousnerve   highly
    Reproductivefemale systemplacenta  moderately
    Respiratorylung   highly
     respiratory tractlarynx  predominantly
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • a UBA domain
    • HOMOLOGY
    interspecies homolog to murine putative S/T kinase MSK
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a serine/threonine kinase
  • essential role for SIK3 in facilitating chondrocyte hypertrophy during skeletogenesis and growth plate maintenance
  • SIK3 induces nuclear export of the deacetylases independent of kinase activity and 14-3-3 binding
  • SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex and thereby the inhibition of ubiquitination of TRAF6
  • mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
  • likely developmental role of SIK3 in hearing and may be required for the maintenance of adult auditory function
  • is a unique negative regulator that suppresses inflammatory molecule gene expression in LPS-stimulated macrophages
  • SIK3, rather than SIK1, SIK2, or AMPKs, acts as the predominant suppressor in gluconeogenic gene expression in the hepatocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • STK11-SIK pathway functions as a key gluconeogenic gatekeeper in the liver
    • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • STK11 acts through SIK2 and SIK3 to promote nucleocytoplasmic trafficking of class IIa HDACs
  • SIK1 and SIK3 negatively regulate TTLR4-mediated signal
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • biliary disorders in Sik3(-/-) mice are associated with the dysregulation of gene expression programs that respond to nutritional stresses and are probably regulated by nuclear receptors
  • Sik3-deficient mice showed dwarfism as they aged, whereas body size was unaffected during embryogenesis