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FLASH GENE
Symbol PADI2 contributors: mct - updated : 18-01-2017
HGNC name peptidyl arginine deiminase, type II
HGNC id 18341
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
poly N-glycosylation sites
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine protein-arginine deiminase
intraspecies homolog to peptidylarginine deiminases
Homologene
FAMILY PAD family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzing the post-translational modification of proteins through the conversion of arginine to citruline in the presence of Ca2+ ions
  • playing an important role during terminal differentiation of epidermal keratinocytes
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • filaggrin, trichoyalin
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
    • cell & other
    REGULATION
    induced by sex steroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS