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FLASH GENE
Symbol PADI2 contributors: mct - updated : 18-01-2017
HGNC name peptidyl arginine deiminase, type II
HGNC id 18341
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary glandsubmaxillary   
Nervousbrain    
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis   Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
poly N-glycosylation sites
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine protein-arginine deiminase
intraspecies homolog to peptidylarginine deiminases
Homologene
FAMILY PAD family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzing the post-translational modification of proteins through the conversion of arginine to citruline in the presence of Ca2+ ions
  • playing an important role during terminal differentiation of epidermal keratinocytes
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • filaggrin, trichoyalin
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
    • cell & other
    REGULATION
    induced by sex steroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS