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FLASH GENE
Symbol RPH3A contributors: - updated : 12-10-2005
HGNC name rabphilin 3A homolog (mouse)
HGNC id 17056
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two C2 domains
  • a FYVE-type zinc finger domain
  • a RabBD (Rab-binding) domain
    • HOMOLOGY
    interspecies homolog to rattus rabphilin 3A
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane of synaptic vesicles
    basic FUNCTION
  • playing a role in neurotransmitter release by
    • regulating membrane flow in the nerve terminal
  • involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with annexin A4 and synaptotagmin 1( C2B domain interacts directly with the N-terminus of annexin A4 )
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS