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FLASH GENE
Symbol RPH3A contributors: - updated : 12-10-2005
HGNC name rabphilin 3A homolog (mouse)
HGNC id 17056
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
 braindiencephalonamygdala  
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two C2 domains
  • a FYVE-type zinc finger domain
  • a RabBD (Rab-binding) domain
    • HOMOLOGY
    interspecies homolog to rattus rabphilin 3A
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane of synaptic vesicles
    basic FUNCTION
  • playing a role in neurotransmitter release by
    • regulating membrane flow in the nerve terminal
  • involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with annexin A4 and synaptotagmin 1( C2B domain interacts directly with the N-terminus of annexin A4 )
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS