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FLASH GENE
Symbol RPH3A contributors: - updated : 12-10-2005
HGNC name rabphilin 3A homolog (mouse)
HGNC id 17056
Location 12q24.11      Physical location : 113.229.548 - 113.336.682
Synonym name
  • rabphilin
  • exophilin-1
  • Synonym symbol(s) KIAA0985
    DNA
    TYPE functioning gene
    STRUCTURE 107.00 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ32356 12q24.13 hypothetical protein FLJ32356 LNK 12q24 hypothetical protein FLJ32356 SCA2 12q24.1 spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2) BRAP 12q24 BRCA1 associated protein MGC5601 12q24.13 hypothetical protein MGC5601 ALDH2 12q24.2 aldehyde dehydrogenase 2 family (mitochondrial) FLJ39616 12q24.13 apoptosis-related protein PNAS-1 MAPKAPK5 12q24.12 mitogen-activated protein kinase-activated protein kinase 5 ADAM1 12q24.13 a disintegrin and metalloproteinase domain 1 (fertilin alpha) pseudogene LOC89894 12q24.13 hypothetical protein BC000282 C12orf8 12q24.13 chromosome 12 open reading frame 8 FLJ13089 12q24.13 hypothetical protein FLJ13089 FLN29 12q FLN29 gene product FLJ30092 12q24.13 AF-1 specific protein phosphatase FLJ34154 12q24.13 hypothetical protein FLJ34154 RPL6 12q23-q24.1 ribosomal protein L6 PTPN11 12q24.1 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) RPH3A 12q24.11 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) OAS1 12q24.2 2',5'-oligoadenylate synthetase 1, 40/46kDa OAS3 12q24.1 2'-5'-oligoadenylate synthetase 3, 100kDa OAS2 12q24.2 2'-5'-oligoadenylate synthetase 2, 69/71kDa DTX1 12q24.1 deltex homolog 1 (Drosophila) RASAL1 12q23-q24 RAS protein activator like 1 (GAP1 like) LOC387885 12 LOC387885 DDX54 12q24.21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 FLJ14827 12q24.21 hypothetical protein FLJ14827 LOC115811 12q24.21 hypothetical protein BC013151 TPCN1 12q24.21 two pore segment channel 1 FLJ22233 LOC196463 12q24.21 hypothetical protein LOC196463 SDS 12q24.1 serine dehydratase SDS-RS1 12q24.21 serine dehydratase related sequence 1 LHX5 12q24.31-q24.32 LIM homeobox protein 5 KIAA0682 12q23.3-q24.2 LIM homeobox protein 5
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
     braindiencephalonamygdala  
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two C2 domains
  • a FYVE-type zinc finger domain
  • a RabBD (Rab-binding) domain
  • HOMOLOGY
    interspecies homolog to rattus rabphilin 3A
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane of synaptic vesicles
    basic FUNCTION
  • playing a role in neurotransmitter release by
  • regulating membrane flow in the nerve terminal
  • involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with annexin A4 and synaptotagmin 1( C2B domain interacts directly with the N-terminus of annexin A4 )
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS