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FLASH GENE
Symbol NTNG1 contributors: mct/npt - updated : 04-12-2019
HGNC name netrin G1
HGNC id 23319
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one laminin EGF-like domain
  • one laminin N-terminal domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • UNC6/netrin family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in nervous system development
  • promotes neurite outgrowth of both axons and dendrites
  • implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
  • axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development) (Lin 2009)
  • NTGN1/LRRC4C, NTGN2/LRRC4 interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
  • pre-synaptic NTNG1 and NTNG2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC4C interact with the presynaptic ligands netrin-G1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    and deleted in Rett syndrome with t(1;7)(p22;q32)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS