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FLASH GENE
Symbol NTNG1 contributors: mct/npt - updated : 04-12-2019
HGNC name netrin G1
HGNC id 23319
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonthalamus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text CNS midbrain and mindbrain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one laminin EGF-like domain
  • one laminin N-terminal domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • UNC6/netrin family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in nervous system development
  • promotes neurite outgrowth of both axons and dendrites
  • implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
  • axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development) (Lin 2009)
  • NTGN1/LRRC4C, NTGN2/LRRC4 interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
  • pre-synaptic NTNG1 and NTNG2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC4C interact with the presynaptic ligands netrin-G1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    and deleted in Rett syndrome with t(1;7)(p22;q32)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS