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FLASH GENE
Symbol FASTKD2 contributors: mct - updated : 24-03-2014
HGNC name FAST kinase domains 2
HGNC id 29160
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal two potential traslation-initiation methionine residues
  • C-terminal FAST kinase domain
    • HOMOLOGY
    intraspecies homolog to cell cycle progression 2 protein
    Homologene
    FAMILY
  • FAST kinase family, FASTKD family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • protein kinase activity, playing a role in mitochondrial apoptosis
  • may be having a role in the finely-tuned regulation of heath production by mitochondria
  • mitochondrial protein essential for cellular respiration
  • DHX30 and DDX28 and FASTKD2 are required for mitochondrial ribosome biogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    repressed by DIF-1 complex, found to repress FASTKD2, a putative proapoptotic gene, in breast cancer cells (Pubmed 21444724)
    Other regulation of FASTKD2 by ITGB3BP and the DIF-1 complex acts is a novel death switch that selectively modulates apoptosis in breast cancer (Pubmed 21444724)
    ASSOCIATED DISORDERS
    corresponding disease(s) ECMBA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    associated with COX deficiency in skeletal muscle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS