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FLASH GENE
Symbol FAIM2 contributors: mct/npt/pgu - updated : 12-07-2016
HGNC name Fas apoptotic inhibitory molecule 2
HGNC id 17067
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven membrane-spanning domains
  • possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8)
  • a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic
    • HOMOLOGY
    interspecies homolog to rattus N-methyl-D-aspartate receptor glutamate binding chain
    Homologene
    FAMILY
  • BI1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • localized in the Golgi apparatus (TMBIM1-3)
    • basic FUNCTION
  • belongs to a new cytoprotective family with evolutionarily conserved functions in the prevention of programmed cell death
  • plays an important role in the regulation of immune responses
  • endogenous inhibitor of FASLG-mediated neuronal death and it mediates the FASLG resistance of CNS differentiated neurons
  • play a role in apoptosis
  • reduce the CaČ&
    • 8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting CaČ&
    8314; concentration
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism SNP associated to obesity risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS