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FLASH GENE

Symbol

FAIM2

contributors: mct/npt/pgu - updated : 12-07-2016

HGNC name	Fas apoptotic inhibitory molecule 2
HGNC id	17067

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	37.09 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012306 12 - 4703 NP_036438 35 316 - 2007 17912957

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus   highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven membrane-spanning domains
	possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8)
	a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic

HOMOLOGY

interspecies

homolog to rattus N-methyl-D-aspartate receptor glutamate binding chain

Homologene

FAMILY

BI1 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	localized in the Golgi apparatus (TMBIM1-3)

basic FUNCTION	belongs to a new cytoprotective family with evolutionarily conserved functions in the prevention of programmed cell death
	plays an important role in the regulation of immune responses
	endogenous inhibitor of FASLG-mediated neuronal death and it mediates the FASLG resistance of CNS differentiated neurons
	play a role in apoptosis
	reduce the Ca²&
	8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting Ca²&
	8314; concentration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to obesity

Variant & Polymorphism SNP	associated to obesity risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS