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FLASH GENE
Symbol FAIM2 contributors: mct/npt/pgu - updated : 12-07-2016
HGNC name Fas apoptotic inhibitory molecule 2
HGNC id 17067
Location 12q13.12      Physical location : 50.260.679 - 50.297.720
Synonym name
  • lifeguard
  • related to rat N-methyl-D-aspartate receptor glutamate binding chain
  • transmembrane BAX inhibitor motif containing 2
  • neural membrane protein 35
    • Synonym symbol(s) NMP35, KIAA0950, LFG, LIFEGUARD, TMBIM2, NGP35
    DNA
    TYPE functioning gene
    STRUCTURE 37.09 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4703 35 316 - 2007 17912957
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven membrane-spanning domains
  • possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8)
  • a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic
    • HOMOLOGY
    interspecies homolog to rattus N-methyl-D-aspartate receptor glutamate binding chain
    Homologene
    FAMILY
  • BI1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • localized in the Golgi apparatus (TMBIM1-3)
    • basic FUNCTION
  • belongs to a new cytoprotective family with evolutionarily conserved functions in the prevention of programmed cell death
  • plays an important role in the regulation of immune responses
  • endogenous inhibitor of FASLG-mediated neuronal death and it mediates the FASLG resistance of CNS differentiated neurons
  • play a role in apoptosis
  • reduce the CaČ&
    • 8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting CaČ&
    8314; concentration
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism SNP associated to obesity risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS