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FLASH GENE

Symbol

CBX6

contributors: npt/mct - updated : 14/10/2008

HGNC name	chromobox homolog 6
HGNC id	1556

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.1      Physical location : 39.260.263 - 39.268.258
Synonym name	Drosophila polycomb-like (PcG) chromobox homolog 6, mouse ortholog

DNA

TYPE	functioning gene
STRUCTURE	8.01 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D22S283 - TRA1 - CBX6 - D22S272 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CBX6 5 - 3284 43 412 - Dunham (1999)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Lymphoid/Immune spleen       highly Nervous nerve       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a chromatin organization modifier (chromo) domain conserved and chromobox regions were dispensable for chromatin association

HOMOLOGY

interspecies	homolog to Drosophila polycomb-like (PcG) chromobox 6
	homolog to murine Numbl

Homologene

FAMILY

Polycomb group proteins family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in the compaction of chromatin
	transcriptional repressor recruited to many developmental control genes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS