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FLASH GENE
Symbol PLXNB3 contributors: mct - updated : 22-01-2014
HGNC name plexin B3
HGNC id 9105
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
from the N terminal a SEMA homology domain followed by three cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS,a single transmembrane segment (1TM)
HOMOLOGY
interspecies ortholog to murine Plxnb3
homolog to Drosophila plexB
homolog to C.elegans plx-2
Homologene
FAMILY calcium-dependent cell adhesion molecule family
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • highly potent stimulator of neurite outgrowth
  • may influence cognitive performance, and the development of white matter
  • SEMA5A and its receptor PLXNB3 play an important role in the invasion and metastasis of gastric carcinoma
  • under physiological conditions Plexin-B3 is not essential for the development and function of the central nervous system
  • SEMA5A and PLXNB3 impede motility but promote differentiation of human gliomas
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS