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FLASH GENE

Symbol

PLXNB3

contributors: mct - updated : 22-01-2014

HGNC name	plexin B3
HGNC id	9105

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	15.15 kb     36 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - DXS1193 - IDS /ABCD1 - AVPR2 - CXorf12 - EMD EMD - PLXNB3 - MPP1 - F8 - qter
Authors	GeneMap

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001163257 37 - 6377 NP_001156729 - 1932 - - NM_005393 36 - 6211 NP_005384 - 1909 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous oligodendrocyte Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

from the N terminal a SEMA homology domain followed by three cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS,a single transmembrane segment (1TM)

HOMOLOGY

interspecies	ortholog to murine Plxnb3
	homolog to Drosophila plexB
	homolog to C.elegans plx-2

Homologene

FAMILY

calcium-dependent cell adhesion molecule family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	highly potent stimulator of neurite outgrowth
	may influence cognitive performance, and the development of white matter
	SEMA5A and its receptor PLXNB3 play an important role in the invasion and metastasis of gastric carcinoma
	under physiological conditions Plexin-B3 is not essential for the development and function of the central nervous system
	SEMA5A and PLXNB3 impede motility but promote differentiation of human gliomas

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS