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FLASH GENE
Symbol PLXNC1 contributors: mct/npt - updated : 16-03-2010
HGNC name plexin C1
HGNC id 9106
Location 12q22      Physical location : 94.542.498 - 94.699.224
Synonym name
  • plexin (semaphorin receptor)
  • receptor for virally-encoded semaphorin
  • poxvirus A39R protein
  • CD232 antigen
  • virus-encoded semaphorin protein receptor
  • Synonym symbol(s) VESPR, PLEXC1, CD232, PLXN-C1
    DNA
    TYPE functioning gene
    STRUCTURE 156.73 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map D12S312 - D12S1345 - D12S327 , PLXNC1 - D12S362 - HAL HAL - D12S1657
    Physical map
    BTG1 12q22 B-cell translocation gene 1, anti-proliferative LOC387872 12 hypothetical gene supported by BC044741 LOC390351 12 similar to 60S ribosomal protein L21 LOC283388 12q22 similar to guanine nucleotide exchange factor (1B384) EEA1 12q21.31 early endosome antigen 1, 162kD LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6 LOC387875 12 LOC387875 LOC283412 12q23.1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) METAP2 12q22 methionyl aminopeptidase 2 USP44 12q21.33 ubiquitin specific protease 44 NTN4 12q22-q23 netrin 4 SNRPF 12q21.33 small nuclear ribonucleoprotein polypeptide F FLJ40089 12q23.1 hypothetical protein FLJ40089 MGC35366 12q23.1 hypothetical protein MGC35366 HAL 12q22-q23.1 histidine ammonia-lyase LTA4H 12q22 leukotriene A4 hydrolase ELK3 12q22-q23.1 ELK3, ETS-domain protein (SRF accessory protein 2) PCTK2 12q23.1 PCTAIRE protein kinase 2 FLJ31514 12q23.1 hypothetical protein FLJ31514 FLJ44112 12q23.1 FLJ44112 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 5121 - 1568 - Olsen (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Nervousneuron
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SEMA homology domain
  • two cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • virus-encoded receptor for the semaphorin 7A (SEMA7A)
  • may be involved in the regulation of leukocyte movement
  • potential tumor suppressor protein in melanoma progression, and loss of Plexin C1 expression may promote melanoma invasion and metastasis through loss of inhibitory signaling on cofilin activation (Scott 2009)
  • involved in neural and vascular patterning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for SEMA7A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in metastatic melanoma compared with primary melanoma (possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma) (Lazova 2009)
    constitutional     --over  
    in proliferating hemangiomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS