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FLASH GENE
Symbol PLXNC1 contributors: mct/npt - updated : 16-03-2010
HGNC name plexin C1
HGNC id 9106
Location 12q22      Physical location : 94.542.498 - 94.699.224
Synonym name
  • plexin (semaphorin receptor)
  • receptor for virally-encoded semaphorin
  • poxvirus A39R protein
  • CD232 antigen
  • virus-encoded semaphorin protein receptor
  • Synonym symbol(s) VESPR, PLEXC1, CD232, PLXN-C1
    DNA
    TYPE functioning gene
    STRUCTURE 156.73 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map D12S312 - D12S1345 - D12S327 , PLXNC1 - D12S362 - HAL HAL - D12S1657
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 5121 - 1568 - Olsen (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Nervousneuron
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SEMA homology domain
  • two cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • virus-encoded receptor for the semaphorin 7A (SEMA7A)
  • may be involved in the regulation of leukocyte movement
  • potential tumor suppressor protein in melanoma progression, and loss of Plexin C1 expression may promote melanoma invasion and metastasis through loss of inhibitory signaling on cofilin activation (Scott 2009)
  • involved in neural and vascular patterning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for SEMA7A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in metastatic melanoma compared with primary melanoma (possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma) (Lazova 2009)
    constitutional     --over  
    in proliferating hemangiomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS