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FLASH GENE

Symbol

ARHGAP5

contributors: mct/npt/pgu - updated : 25-10-2013

HGNC name	Rho GTPase activating protein 5
HGNC id	675

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL14QP

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland

Susceptibility

Variant & Polymorphism

Candidate gene	cortical blindness
Marker
Therapy target

ANIMAL & CELL MODELS

mice lacking Arhgap5 display several major defects including deficits in the formation of major forebrain commissures, including the corpus callosum and anterior commissure