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FLASH GENE
Symbol ARHGAP1 contributors: mct/npt - updated : 30-09-2009
HGNC name Rho GTPase activating protein 1
HGNC id 673
Location 11p11.2      Physical location : 46.698.633 - 46.722.120
Synonym name
  • CDC42 GTPase-activating protein
  • GTPase-activating protein rhoOGAP
  • Synonym symbol(s) CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP
    DNA
    TYPE functioning gene
    STRUCTURE 23.49 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D11S1361 - D11S1344 - ARHGAP1 - CD82 - SERPING1 - D11S1357 - qter
    Authors Gene Map (98)
    Physical map
    DKFZp779M0652 11p11.2 hypothetical protein DKFZp779M0652 SLC35C1 11p11.2 solute carrier family 35, member C1 CRY2 11p12-q21.1 cryptochrome 2 (photolyase-like) MAPK8IP1 11p12-p11.2 mitogen-activated protein kinase 8 interacting protein 1 LOC143678 11p11.2 similar to RIKEN cDNA 1700021K07 PEX16 11p11.11 peroxisomal biogenesis factor 16 GYLTL1B 11p11.2 glycosyltransferase-like 1B BHC80 11p11.2 glycosyltransferase-like 1B CREB3L1 11p11.2 cAMP responsive element binding protein 3-like 1 DGKZ 11p11.2 diacylglycerol kinase, zeta 104kDa MDK 11p11.2 midkine (neurite growth-promoting factor 2) CHRM4 11p12-p11.2 cholinergic receptor, muscarinic 4 LOC387765 11 LOC387765 FLJ20294 11p11.2 hypothetical protein FLJ20294 FLJ32675 11p11.2 hypothetical protein FLJ32675 KIAA0652 11p12-q11 hypothetical protein FLJ32675 ARHGAP1 11p12-q12 Rho GTPase activating protein 1 ZNF408 11p11.2 zinc finger protein 408 F2 11p11-q12 coagulation factor II (thrombin) ch-TOG 11p11.2 KIAA0097 gene product LRP4 11p12-p11.2 low density lipoprotein receptor-related protein 4 MGC4707 11p11.2 hypothetical protein MGC4707 ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain MYBPC3 11p11.2 myosin binding protein C, cardiac SPI1 11p12 spleen focus forming virus (SFFV) proviral integration oncogene spi1 SLC39A13 11p11.2 solute carrier family 39 (zinc transporter), member 13 PSMC3 11p13-p12 proteasome (prosome, macropain) 26S subunit, ATPase, 3 RAPSN 11p11.2-p11.1 receptor-associated protein of the synapse, 43kD
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3372 - 439 - Lancaster (1994)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Endocrinepancreas   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proline-rich, Src homology 3 (SH3) binding domain
  • three consensus box regions characteristic of Rho GAP
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulating the basal apoptosis of cells through the JNK pathway
  • promotes inactivation of CDC42, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration (Shen 2008)
  • inhibitor of active-state small Rho GTPases and counter-regulatory mediator for tubule formation
  • implicated in the regulation of cell motility, adhesion, proliferation, and apoptosis (Li 2009)
  • regulates the vimentin network through the CDC42-PAK pathway in smooth muscle cells during 5-hydroxytryptamine stimulation (Li 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NDL1 (NDLl and ARHGAP1 exhibit leading-edge localization in migrating cells)(Shen 2008)
  • binds NDEL1 to modulate CDC42 activity at the leading edge of migrating cells (Shen 2008))
  • cell & other
    REGULATION
    Other its activity is regulated upon contractile activation, which is mediated by intracellular ROS (Li 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in tubular microvascular endothelial cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Cdc42GAP-/- mouse embryonic fibroblasts and/or tissues display reduced population doubling, significantly dampened DNA damage repair activity after DNA-damaging agent treatment, accumulated genomic abnormalities, and induction of p53, p16Ink4a, p21Cip1, and senescence-associated beta-galactosidase expressions (Wang 2007)