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FLASH GENE
Symbol SOCS1 contributors: mct/pgu - updated : 11-07-2017
HGNC name suppressor of cytokine signaling 1
HGNC id 19383
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
silenced by methylation in hepatocellular carcinoma (loss of function) and pancreatic cancer
tumoral   LOH    
in newly diagnosed acute myeloid leukemia in progression
constitutional     --low  
in idiopathic pulmonary fibrosis (IPF), resulted in increased collagen and parenchymal fibrosis production
tumoral     --over  
significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
constitutional     --low  
significantly down-regulated in multiple sclerosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • strong associations between APC, GSTP1 and SOCS1 gene promoter methylation and the risk of HCC, suggesting these to be promising biomarkers for hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
    knockout mice