Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTPN21 contributors: mct - updated : 06-09-2016
HGNC name protein tyrosine phosphatase, non-receptor type 21
HGNC id 9651
Location 14q31.3      Physical location : 88.932.122 - 89.021.123
Synonym name protein tyrosine phosphatase D1
Synonym symbol(s) PTPD1, PTPRL10
EC.number 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 89.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence
MAPPING cloned Y linked N status confirmed
Map cen - D14S67 - D14S1068 - PTPN21 - D14S58 - D14S256 - D14S1066 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 6215 133.2 1174 - 2008 18223254
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
 thyroid   highly
Hearing/Equilibriumear   predominantly
Lymphoid/Immunethymus    
Reproductivefemale systemovary  moderately
Skin/Tegumentskin   moderately
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal sequence homologous to the FERM (four point one ezrin-radixin-moesin) domain protein family
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to rattus Ptpn21 (88.6 pc)
    homolog to murine Ptpn21 (89.3 pc)
    Homologene
    FAMILY
  • protein tyrosine phosphatase (PTP) family
  • non-receptor class subfamily
  • CATEGORY enzyme , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microfilament
    text
  • localized along actin filaments and at adhesion plaques
  • KIF16B anchors PTPN21 to endosomes
  • localisation of PTPN21 at the plasma membrane was mediated by its FERM domain and enabled the formation of EGFR/PTPN21-containing signalling complexes that pre-existed at the plasma membrane before EGF stimulation
  • basic FUNCTION
  • promoting the cytoskeleton events that induce cell adhesion and migration
  • signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation
  • exerts major effects on cell adhesion, scattering, and migration
  • cytosolic non-receptor protein-tyrosine phosphatase, stimulates the SRC-EGF transduction pathway
  • required for growth and motility of urothelial cancer cells, and its expression in bladder cancer tissue positively correlates with tumor stage and invasive potential
  • regulates critical aspects of cell-cell communication, growth and motility of urothelial cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BMX, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains (increasing the activation of STAT3)
  • AKAP1 also targets SRC tyrosine kinase to mitochondria via PTPN21
  • its endosomal localization is mediated by interaction with KIF16B, an endosomal kinesin that modulates receptor
  • also interacts with KIF1C, an evolutionarily related KIF family member that is potentially involved in retrograde transport of vesicles from the Golgi to the endoplasmic reticulumrecycling at the plasma membrane
  • interacts and colocalizes with KIF16B through its FERM domain
  • PTPN21-SRC complex also associates with AKAP1, a protein kinase A-anchoring protein that attaches to the outer mitochondrial membrane
  • PTPN21 exerts pro-neuronal survival and neuritic elongation via ERBB4/NRG3 signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    markedly increased in bladder cancer tissue samples and is positively correlated with the grading and invasiveness potential of these tumors
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP
  • two non-synonymous markers in PTPN21, are associated with schizophrenia
  • Candidate gene
    Marker
  • represents a novel marker for bladder cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    possible therapeutic target for bladder cancer
    ANIMAL & CELL MODELS